Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 67, Issue 41, Pages 11408-11419Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b04411
Keywords
inflammatory bowel disease; Lycium barbarum L.; dextran sulfate sodium; 2-O-beta-D-glucopyranosyl-L-ascorbic acid; anti-inflammatory activity; gut microbiota
Funding
- Undergraduate Student Research Training Program of Nanjing Agricultural University [1818C01]
- Key Research and Development Project - Ningxia Hui Autonomous Region of China [2018YBZD1915]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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In this study, the effects of 2-O-beta-D-glucopyranosyl-L-ascorbic acid (AA-2 beta G), a natural ascorbic acid derivative from the fruits of Lycium barbarum, on treating the dextran sulfate sodium (DSS)-induced colitis in mice were investigated. The results revealed that AA-2 beta G had palliating effects on DSS-induced inflammatory bowel disease (IBD) in terms of slowing down the trends of body weight and solid fecal mass loss, reducing colitis disease activity index, improving serum physiological and biochemical indicators, increasing colon length, blocking proinflammatory cytokines, and increasing tight junction proteins. Additionally, AA-2 beta G treatment could promote the production of short-chain fatty acids and modulate the composition of the gut microbiota. The key bacteria related to IBD were found to be Porphyromonadaceae, Prevotellaceae, Rikenellaceae, Parasutterella, Parabacteroides, and Clostridium. The results indicated that AA-2 beta G might treat IBD through the regulation of gut microbiota, suggesting that AA-2 beta G has the potential to be used as a dietary supplement in the treatment of IBD.
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