Journal
INTERNATIONAL JOURNAL OF STROKE
Volume 14, Issue 8, Pages 792-802Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1747493019879657
Keywords
Stroke; rehabilitation; recovery; consensus; trial design; GO NO-GO
Categories
Funding
- Canadian Institutes of Health Research (CIHR) CaSTOR (Canadian Stroke Trials for Optimized Results) Group
- Heart and Stroke Canadian Partnership for Stroke Recovery
- NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery [APP1077898]
- Ipsen Pharma
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A major goal of the Stroke Recovery and Rehabilitation Roundtable (SRRR) is to accelerate development of effective treatments to enhance stroke recovery beyond that expected to occur spontaneously or with current approaches. In this paper, we describe key issues for the next generation of stroke recovery treatment trials and present the Stroke Recovery and Rehabilitation Roundtable Trials Development Framework (SRRR-TDF). An exemplar (an upper limb recovery trial) is presented to demonstrate the utility of this framework to guide the GO, NO-GO decision-making process in trial development.
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