Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 570, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2019.118663
Keywords
Carrier-free; Nanodrug; Self-assembly; Synergistic cancer therapy
Categories
Funding
- National Natural Science Foundation of China [81972832, 81673698]
- Ministry of Science and Technology of the People's Republic of China [2015CB931804]
- Natural Science Foundation of Fujian Province, China [2018J01895]
- Scientific Research Training Program for Undergraduate of Fuzhou University [25055]
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Nanoformulations with advantages in drug delivery, safety and pharmacodynamics have been booming as a promising strategy for cancer therapy. However, the traditional nanocarrier still suffers from the low drug loading capacity, potential systematic toxicity, unclear metabolism, and other uncertainties. To overcome these issues, carrier-free nanodrugs with desirable bioactivity were developed rapidly and drawn considerable attention. Meanwhile, the multifunctional self-delivery nanoarcheticture fabricated by a simple and green method, has significant advantages in synergistic cancer therapy and inhibition of multidrug resistant (MDR). Till now, carrier-free nanoparticles for tumor theranostics, phototherapy, chemotherapy, diagnose and synergistic therapy, have made outstanding progress. In this review, we make an integrated and exhaustive overview of lately reports on carrier-free nanodrug delivery systems formed by several active agents. We summarize the self-assembly and modified strategies, with emphasis on application superiority of carrier-free nanocrystal, and give new insight into the establishment of ideal nanosystems for cancer treatment.
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