Journal
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume 130, Issue 4, Pages 330-335Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207454.2019.1681994
Keywords
Vestibular migraine; inflammatory mediators; inflammasome; vascular neuropeptides; cytokine; headache
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Funding
- Istanbul University Research Fund [BAP-22652]
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Objectives: Vestibular migraine (VM) is an under-recognized entity with substantial burden for the individual and society. The underlying mechanism of VM and its distinction from other migraine mechanisms still remain unclear. Inflammatory pathways have been suggested to contribute to vestibular migraine. Our aim was to further investigate the possible role of inflammation in the pathophysiology of VM. Methods: We recruited 30 patients with VM diagnosed according to ICHD-3 criteria and 50 gender- and age-matched controls. Blood samples were obtained from 11 VM patients during an attack and from 13 VM patients under prophylactic treatment. Plasma levels of calcitonin gene related peptide (CGRP), neurokinin A (NKA), substance P (SP), NLRP1, NLRP3, caspase-1, IL-1 beta, IL-6, TNF-alpha and NF kappa B were measured by ELISA. Results: IL-6 levels were significantly reduced in VM patients, whereas levels of other inflammation parameters were comparable to those of healthy controls. Levels of inflammatory mediators were not correlated with clinical parameters. Likewise, there were no significant differences among VM patients with and without headache attack and prophylactic treatment. Conclusion: Our results argue against involvement of systemic inflammation in the pathophysiology of VM.
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