Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 78, Issue -, Pages 197-203Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2016.01.019
Keywords
Paeoniflorin; Breast cancer; Proliferation; Invasion; Notch-1
Funding
- Wu Jieping Medical Foundation [320.6750.14070]
- Science and Technology Fund of Liaoning Province [20141183]
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Paeoniflorin (PF), one of the major active ingredients of Chinese peony, was reported to possess antitumor effect. However, the role of PF in breast cancer remains to be clarified. Therefore, in this context, the present study investigated the effects of PF on breast cancer cell proliferation and invasion, as well as the underlying mechanism. Our results found that PF suppressed the proliferation and invasion of breast cancer cells. We further demonstrated that PF down-regulated the expression of Notch-1; in addition, overexpression of Notch-1 reversed PF-inhibited proliferation and invasion, and knockdown of Notch-1 enhanced PF-inhibited proliferation and invasion in breast cancer cells. In conclusion, the present study suggests that PF inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway. Therefore, PF may represent a chemopreventive and/or therapeutic agent in the prevention of breast cancer. (C) 2016 Elsevier Masson SAS. All rights reserved.
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