Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/ijms20215284
Keywords
heat shock protein inhibitors; molecular chaperones; HSP90; HSP70; HSP27; concurrent therapy; cancer therapy
Funding
- German Research Foundation DFG [SFB824/3]
- Russian Foundation for Basic Research project [19-08-00024]
- Russian Scientific Foundation [19-74-20161]
- Technische Universitat Munchen (TUM) within the DFG
- Russian Science Foundation [19-74-20161] Funding Source: Russian Science Foundation
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Most molecular chaperones belonging to heat shock protein (HSP) families are known to protect cancer cells from pathologic, environmental and pharmacological stress factors and thereby can hamper anti-cancer therapies. In this review, we present data on inhibitors of the heat shock response (particularly mediated by the chaperones HSP90, HSP70, and HSP27) either as a single treatment or in combination with currently available anti-cancer therapeutic approaches. An overview of the current literature reveals that the co-administration of chaperone inhibitors and targeting drugs results in proteotoxic stress and violates the tumor cell physiology. An optimal drug combination should simultaneously target cytoprotective mechanisms and trigger the imbalance of the tumor cell physiology.
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