4.7 Review

PI3K/mTOR Pathway Inhibition: Opportunities in Oncology and Rare Genetic Diseases

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Overgrowth syndromes - clinical and molecular aspects and tumour risk

Frederic Brioude et al.

NATURE REVIEWS ENDOCRINOLOGY (2019)

Article Genetics & Heredity

First evidence of a therapeutic effect of miransertib in a teenager with Proteus syndrome and ovarian carcinoma

Chiara Leoni et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2019)

Review Biochemistry & Molecular Biology

Targeting PI3K signaling in cancer: Challenges and advances

Maria Chiara De Santis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

Article Medicine, General & Internal

Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer

Fabrice Andre et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Biochemistry & Molecular Biology

The PTEN-PI3K Axis in Cancer

Antonella Papa et al.

BIOMOLECULES (2019)

Article Medicine, Research & Experimental

MicroRNA-21-5p targeting PDCD4 suppresses apoptosis via regulating the PI3K/AKT/FOXO1 signaling pathway in tongue squamous cell carcinoma

Changfu Liu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2019)

Review Surgery

The other mTOR complex: New insights into mTORC2 immunobiology and their implications

Helong Dai et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2019)

Review Clinical Neurology

Review: Mechanistic target of rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy

E. Marsan et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2018)

Review Immunology

Activated PI3 Kinase Delta Syndrome: From Genetics to Therapy

David Michalovich et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Multidisciplinary Sciences

Targeted therapy in patients with PIK3CA-related overgrowth syndrome

Quitterie Venot et al.

NATURE (2018)

Review Biochemistry & Molecular Biology

Cancer-Associated PIK3CA Mutations in Overgrowth Disorders

Ralitsa R. Madsen et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Review Genetics & Heredity

mTOR inhibitor therapy as a disease modifying therapy for tuberous sclerosis complex

David Neal Franz et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS (2018)

Review Clinical Neurology

New developments in understanding focal cortical malformations

Albert J. Becker et al.

CURRENT OPINION IN NEUROLOGY (2018)

Article Endocrinology & Metabolism

Everolimus in Patients With Advanced Follicular-Derived Thyroid Cancer: Results of a Phase II Clinical Trial

Tatiana C. Schneider et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Article Medicine, General & Internal

Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

R. S. Finkel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Chemistry, Medicinal

Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors

Klemens Hoegenauer et al.

ACS MEDICINAL CHEMISTRY LETTERS (2017)

Review Biochemistry & Molecular Biology

The PI3K Pathway in Human Disease

David A. Fruman et al.

Article Genetics & Heredity

Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia

Jae Seok Lim et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2017)

Article Dermatology

Mosaic Disorders of the PI3K/PTEN/AKT/TSC/mTORC1 Signaling Pathway

Neera Nathan et al.

DERMATOLOGIC CLINICS (2017)

Article Genetics & Heredity

Nephroblastomatosis or Wilms tumor in a fourth patient with a somatic PIK3CA mutation

Karen W. Gripp et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2016)

Review Genetics & Heredity

Somatic overgrowth disorders of the PI3K/AKT/mTOR pathway & therapeutic strategies

Kim M. Keppler-Noreuil et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS (2016)

Article Biochemistry & Molecular Biology

Brain somatic mutations in MTOR leading to focal cortical dysplasia

Jae Seok Lim et al.

BMB REPORTS (2016)

Article Oncology

Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models

I. A. Netland et al.

BMC CANCER (2016)

Article Multidisciplinary Sciences

Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement

Lawrence S. Hsieh et al.

NATURE COMMUNICATIONS (2016)

Article Medicine, General & Internal

Tuberous sclerosis complex

Elizabeth P. Henske et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Clinical Neurology

Familial cortical dysplasia type IIA caused by a germline mutation in DEPDC5

Thomas Scerri et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)

Article Clinical Neurology

Incidence, prevalence and aetiology of seizures and epilepsy in children

Peter Camfield et al.

EPILEPTIC DISORDERS (2015)

Article Genetics & Heredity

Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum

Kim M. Keppler-Noreuil et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2014)

Article Biochemistry & Molecular Biology

An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2

Kameswaran Ravichandran et al.

HUMAN MOLECULAR GENETICS (2014)

Review Biotechnology & Applied Microbiology

PI3K and cancer: lessons, challenges and opportunities

David A. Fruman et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Medicine, General & Internal

PI3Kδ Inhibition by Idelalisib in Patients with Relapsed Indolent Lymphoma

Ajay K. Gopal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Clinical Neurology

Everolimus Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex

Darcy A. Krueger et al.

ANNALS OF NEUROLOGY (2013)

Article Biochemistry & Molecular Biology

Mammalian Target of Rapamycin (mTOR) Pathways in Neurological Diseases

Michael Wong

Biomedical Journal (2013)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

Article Genetics & Heredity

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

Marjorie J. Lindhurst et al.

NATURE GENETICS (2012)

Review Oncology

Targeted therapy in rare cancers-adopting the orphans

Javier Munoz et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2012)

Article Medicine, Research & Experimental

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

Nicole A. Neuman et al.

EMBO MOLECULAR MEDICINE (2011)

Review Biotechnology & Applied Microbiology

Rapamycin passes the torch: a new generation of mTOR inhibitors

Don Benjamin et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Article Biochemistry & Molecular Biology

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)

Laura R. Pearce et al.

BIOCHEMICAL JOURNAL (2010)

Article Medicine, General & Internal

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis.

Darcy A. Krueger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Review Oncology

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Jeffrey A. Engelman

NATURE REVIEWS CANCER (2009)

Article Clinical Neurology

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

Ling-Hui Zeng et al.

ANNALS OF NEUROLOGY (2008)

Article Biochemistry & Molecular Biology

Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis

Dan Ehninger et al.

NATURE MEDICINE (2008)

Review Biochemistry & Molecular Biology

PI3K pathway alterations in cancer: variations on a theme

T. L. Yuan et al.

ONCOGENE (2008)