An electrochemical study of Atenolol using Patton and Reeder's modified pencil graphite electrode as an electrochemical sensor

An electrochemical sensor has been developed using Patton and Reeder's reagent which is electropolymerised on pencil graphite electrode (PR-PGE) for the selective and sensitive determination of Atenolol (ATN). The cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectra were used to check the analytical applicability of the proposed sensor for the investigation of ATN. To achieve better electrochemical response, the parameters such as pH, scan rate and electron transfer kinetics were determined. Under optimum experimental conditions, the linear calibration curve shows concentration linear range of 0.1-1.8 mu M and the limit of detection 4.9 x 10(-8) M. The proposed sensor shows better selectivity towards the determination of ATN in presence of organic and inorganic interfering species. The analytical performance of the PR-PGE has been studied successfully by determining ATN present in the pharmaceutical sample.

Automated summary

An electrochemical sensor using PR-PGE has been developed for the selective and sensitive determination of Atenolol, with optimized parameters and analytical performance demonstrated in pharmaceutical samples.