Journal
BIOMEDICAL MICRODEVICES
Volume 18, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1007/s10544-016-0033-7
Keywords
Magnetic micropillar; Cell migration; Mechanical stimulation; Polymer actuator
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- CMC Microsystems
- NSERC Vanier Canada Graduate Scholarship
- Izaak Walton Killam Foundation
- University of British Columbia
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We present a study on the application of magnetically actuated polymer micropillar surfaces in modifying the migration behaviour of cells. We show that micropillar surfaces actuated at a frequency of 1 Hz can cause more than a 5-fold decrease in cell migration rates compared to controls, whereas non-actuated micropillar surfaces cause no statistically significant alterations in cell migration rates. The effectiveness of the micropillar arrays in impeding cell migration depends on micropillar density and placement patterns, as well as the direction of micropillar actuation with respect to the direction of cell migration. Since the magnetic micropillar surfaces presented can be actuated remotely with small external magnetic fields, their integration with implants could provide new possibilities for in-vivo tissue engineering applications.
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