Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 143, Issue -, Pages 825-832Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.09.143
Keywords
Chitosan; Copper nanoparticles; Nanocomposite hydrogels
Funding
- Fondecyt [3170272, 11160073]
- Universidad de Talca, Talca, Chile
- Proyecto de Investigacion enlace FONDECYT Universidad de Talca [300061]
- CIPA, CONICYT Regional, GORE BIO-BIO [R17A10003]
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Copper nanoparticles were synthesized via precipitation technique using the pseudonatural cationic chitosan biopolymer as a stabilizing agent. The nanoparticles developed were successfully incorporated into the 1:1 ratio of blended chitosan: pluronic F127 polymer solution and made their nanocomposite hydrogels by solution casting method. The formed copper-based nanocomposite hydrogels were characterized by using Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, scanning electron microscopy-energy dispersive spectroscopy and transmission electron microscopy studies. The antimicrobial activity of the fabricated nanocomposite hydrogels was tested via an inhibition zone process against both E. coli (gram-negative) and S. aureus (gram-positive) bacteria. The results conveyed that the copper-embedded chitosan-pluronic\ F127 nanocomposite hydrogels can be used effectively for antimicrobial applications as well as for wound care applications. (C) 2019 Elsevier B.V. All rights reserved.
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