Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 152, Issue -, Pages 1233-1241Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.10.220
Keywords
Anthocyanin; Pickering emulsion; Octenylsuccinate quinoa starch; Storage stability; Intestinal-targeted delivery
Funding
- Science and Technology Program of Guangzhou, China [201704020080]
- 2019 High Level University Program-Research Foundation for Advanced Talents [G619310013]
- 111 Project [B17018]
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In this study, anthocyanin-loaded water(1)-in-oil-in-water(2) (W-1/O/W-2) double Pickering emulsions stabilized by octenylsuccinate quinoa starch (OSQS) were optimized, and their storage stability and in vitro gastrointestinal wdigestion were evaluated. Novel starch-based double emulsions as anthocyanin cargos were achieved at 2% (w/v of oil) of polyglycerol polyricinoleate concentration, the W-1/O volume proportion of 3:7, 6% (w/v of total volume) of OSQS concentration, and the volume proportion of (W-1/O): W-2 = 6:4 and 5:5. CLSM results evidenced the formation of double Pickering emulsions, and the significant decreases in the encapsulation stability of anthocyanins were closely related to the increases in the droplet size induced by osmotic pressure. Less than 15% of anthocyanins in the double Pickering emulsions was released after incubated for 60 min under simulated stomach conditions; controlled-release of anthocyanins was observed during the 120 min of simulated intestinal digestion, consistent with starch hydrolysis data. These findings will be useful for designing starch-based double Pickering emulsion with intestinal-targeted delivery as a novel carrier of sensitive hydrophilic bioactive compounds. (C) 2019 Elsevier B.V. All rights reserved.
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