Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 155, Issue -, Pages 903-910Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.11.048
Keywords
Electrospinning; Maleilated hyaluronate; Methacrylated poly (vinyl alcohol); Photopolymerization; Wound dressing
Funding
- National Natural Science Foundation of China [51203123, 51773162]
- National Key Research and Development Program of China [2016YFA0101102]
- Hubei Province Technological Innovation Major Project [2019AAA034]
- Project of Wuhan Municipal Science and Technology Bureau [2019010702011335]
- Testing & Analysis Center, Wuhan Textile University
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Although electrospinning of nanofibrous scaffolds benefit to wound healing have been developed at a fast pace, achieving nanofibrous scaffolds with high absorptivity by green electrospinning and crosslinking techniques is still a great challenge. Here, we developed a maleilated hyaluronate/methacrylated poly (vinyl alcohol) (MHA) (MaPVA) composite nanofibers by electrospinning from pure water solvent and followed by photopolymerization to form crosslinking nanofibers network. Electrospinnability of MHA/MaPVA blend systems were investigated and the results shows that themorphology and diameter of the nanofibers were mainly affected by MHA/MaPVA weight ratios by changing viscosity and conductivity of the blend solutions. The crystalline microstructure of the electrospun fibers was not well developed due to intermolecular hydrogen bonding interaction between the molecules of MHA and MaPVA. The photocrosslinking MHA/MaPVA nanofibrous mats can swell to form fibrous hydrogels with high water absorption, meanwhile it is cytocompatible and capable of promoting the cell attachment, which render it great potential for wound dressings. (C) 2019 Elsevier B.V. All rights reserved.
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