Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 140, Issue -, Pages 441-453Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.08.143
Keywords
Cellulose nanofibrils; Collagen; Grafting; Sustained ophthalmic drug delivery; Rheology
Funding
- West Bengal DST
- Centre for Research in Nanoscience and Nanotechnology (CRNN), University of Calcutta
- Department of Polymer Science and Technology, University of Calcutta
- Department ofJute and Fibre Technology, Institute of Jute Technology, the University of Calcutta
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There has been extensive utilization of poloxamer 407 (PM) for the delivery of various ophthalmic drugs aimed at efficient ophthalmic drug delivery approach for longer precomeal residence time along with acceptable bioavailability of drugs. We have studied the effect of nanocellulose grafted collagen (CGC) on the performance of in situ gels based on PM for the controlled in vitro release of Ketorolac Tromethamine (KT). CGC has shown great influence evident by the reduction in PM critical gelation concentration, increased gel strength, and prolonged the release of loaded drugs compared with the virgin PM gel. The engineered nanocomposite formulations established an anomalous diffusion mechanism along with a Fickian diffusion controlled drug release for 15 8.11.75 w/v% CGC reinforced PM. Hence, the synthesized in situ nanocomposites are potential candidates for ophthalmic drug delivery system. (C) 2019 Elsevier B.V. All rights reserved.
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