Journal
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
Volume 91, Issue 1-2, Pages 108-123Publisher
HOGREFE PUBLISHING CORP
DOI: 10.1024/0300-9831/a000614
Keywords
Vitamin D; oxidative stress; lipid peroxidation; protein oxidation
Categories
Funding
- governmental Brazilian agency National Council for Scientific and Technological Development (CNPq)
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The study found that vitamin D deficiency may be associated with lipid peroxidation and protein oxidation, but it is independent of age and gender.
The active vitamin D (1,25(OH)(2)D) acts through a nuclear receptor to perform several functions in cellular metabolism. 1,25(OH)(2)D participates directly in calcium homeostasis, regulates the immune system, nervous system, blood pressure, insulin secretion, among others. Vitamin D deficiency could also be associated with several diseases and increased cellular oxidative damage. The present study aimed to investigate whether lipid peroxidation and/or protein oxidation are affected by vitamin D deficiency and whether sunlight exposure/diet, gender, and age might influence this relationship. Vitamin D concentrations were obtained from the Heart Hospital database and a questionnaire was applied among the 212 participants. We used the inactive vitamin D (25(OH)(2)) in the analyses since 1,25(OH)(2)D has a short half-life and a low blood concentration. Lipid peroxidation and protein oxidation analyses were performed using spectrophotometry. Multivariate analyses suggested the participation of vitamin D deficiency (<30ng/mL) and sunlight/diet in oxidative stress (p <0.05; R-2 MDA: 0.562; R-2 CG: 0.429). Multiple linear regression test show that the age and gender of patients are not interfering in the analyses (p>0.05). Therefore, we suggest that the relationship between vitamin D deficiency and oxidative stress can be independent of age and gender.
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