Journal
INTERNAL MEDICINE
Volume 58, Issue 22, Pages 3313-3318Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.2989-19
Keywords
multicentric Castleman disease; autoimmune hemolytic anemia; tocilizumab; anti-drug antibody
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Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder, and only a few cases have been reported to be complicated with autoimmune hemolytic anemia (AIHA). A 43-year-old man who presented with multiple swollen lymph nodes was diagnosed with iMCD. He was also diagnosed with AIHA based on laboratory findings, including the results of a bone marrow aspiration study. The patient was treated with tocilizumab; however, the effect was limited, probably due to anti-drug antibodies. Tocilizumab was therefore switched to rituximab, and his anemia was improved. Complication with AIHA should be carefully considered when iMCD patients present with severe anemia.
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