Evolutionary trends of neuropeptide signaling in beetles - A comparative analysis of Coleopteran transcriptomic and genomic data

Insects employ neuropeptides to regulate their growth & development, behaviour, metabolism and their internal milieu. At least 50 neuropeptides are known to date, with some ancestral to the insects and others more specific to particular taxa. In order to understand the evolution and essentiality of neuropeptides, we data mined publicly available high quality genomic or transcriptomic data for 31 species of the largest insect Order, the Coleoptera, chosen to represent the superfamilies' of the Adephaga and Polyphaga. The resulting neuropeptide distributions were compared against the habitats, lifestyle and other parameters. Around half of the neuropeptide families were represented across the Coleoptera, suggesting essentiality or at least continuing utility. However, the remaining families showed patterns of loss that did not correlate with any obvious life history parameter, suggesting that these neuropeptides are no longer required for the Coleopteran lifestyle. This may perhaps indicate a decreasing reliance on neuropeptide signaling in insects.