Journal
INFECTION GENETICS AND EVOLUTION
Volume 75, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2019.104001
Keywords
HPeV; Genotype; Children; Acute gastroenteritis; Japan
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Funding
- Japan Society for the Promotion of Science (JSPS) [16H05360]
- Japan Agency for Medical Research and Development, AMED [40104400]
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A total of 972 stool samples were collected from infants and children with acute gastroenteritis (AGE) in pediatric clinics encompassing six localities (Hokkaido, Tokyo, Shizuoka, Kyoto, Osaka, and Saga) in Japan during the 2-year period from July 2014 to June 2016. Sixty six of the samples (6.8%) were found to be positive for human parechovirus (HPeV) by multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and subjected to genotyping based on viral protein 1 (VP1) sequences. Four different HPeV genotypes consisting of HPeV1, -3, -4 and -6 were detected, with HPeV1 Glade B being predominant and followed by HPeV3 and -6. The first-time presence of HPeV1 Glade A in Japan and rare HPeV4 were noted. This study provides up-to-date information on the genetic diversity of HPeV circulating in Japanese infants and children with AGE.
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