Journal
INDOOR AIR
Volume 30, Issue 1, Pages 108-116Publisher
WILEY-HINDAWI
DOI: 10.1111/ina.12612
Keywords
3D printing; CT scanning; deposition; in vitro; mucosal exposure; occupational health
Categories
Funding
- National Natural Science Foundation of China [51778520]
- National Key Research and Development Program of China [2017YFC0702700]
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Exposure to particulate contaminants can cause serious adverse health effects. Deposition on the facial mucosa is an important path of exposure, but it is difficult to conduct direct dose measurement on real human subjects. In this study, we propose an in vitro method to assess the administered doses of micron-sized particles on the eyes and lips in which computed tomographic scanning and three-dimensional printing were used to create a model that includes a face, oropharynx, trachea, the first five generations of bronchi, and lung volume. This realistic model of a face and airway was exposed to monodispersed fluorescent particles released from an incoming jet. The administered dose of particles deposited upon the eyes and lips, as quantified by fluorescence intensity, was determined via a standard wiping protocol. The results show that, in this scenario, the administered doses normalized by source were 2.15%, 1.02%, 0.88%, 2.13%, and 1.55% for 0.6-, 1.0-, 2.0-, 3.0-, and 5.0-mu m particles, respectively. The administered dose of large particles on the mucosa within a given exposure time has great significance. Moreover, the lips suffer a much greater risk of exposure than the eyes and account for more than 80% of total facial mucosa deposition. Our study provides a fast and economical method to assess the administered dose on the facial mucosa on an individual basis.
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