Journal
IMMUNOGENETICS
Volume 72, Issue 1-2, Pages 85-88Publisher
SPRINGER
DOI: 10.1007/s00251-019-01141-w
Keywords
Celiac disease; Gluten; T cell; Epitopes; HLA-DQ2; HLA-DQ8
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Celiac disease is caused by an abnormal intestinal T cell response to cereal gluten proteins. The disease has a strong human leukocyte antigen (HLA) association, and CD4(+) T cells recognizing gluten epitopes presented by disease-associated HLA-DQ allotypes are considered to be drivers of the disease. This paper provides an update of the currently known HLA-DQ restricted gluten T cell epitopes with their names and sequences.
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