Journal
BIOMATERIALS
Volume 76, Issue -, Pages 87-101Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.10.053
Keywords
Mesoporous silica nanoparticle; Tumor-targeted; Magnetic resonance imaging; Theranostic; Precise therapy
Funding
- National Natural Science Foundation of China [51125014, 51233003, 51533006]
- Ministry of Education of China [20120141130003]
- Fundamental Research Funds for the Central Universities [2014203020201, 2014203020204]
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In this paper, a multifunctional theranostic magnetic mesoporous silica nanoparticle (MMSN) with magnetic core was developed for magnetic-enhanced tumor-targeted MR imaging and precise therapy. The gatekeeper beta-cyclodextrin (beta-CD) was immobilized on the surface of mesoporous silica shell via platinum(IV) prodrug linking for reduction-triggered intracellular drug release. Then Arg-Gly-Asp (RGD) peptide ligand was further introduced onto the gatekeeper beta-CD via host-guest interaction for cancer targeting purpose. After active-targeting endocytosis by cancer cells, platinum(IV) prodrug in MMSNs would be restored to active platinum(II) drug in response to the innative reducing microenvironment in cancer cells, resulting in the detachment of beta-CD gatekeeper and thus simultaneously triggering the in situ release of anticancer drug doxorubicin (DOX) entrapped in the MMSNs to kill cancer cells. It was found that with the aid of an external magnetic field, drug loaded MMSNs showed high contrast in MR imaging in vivo and exhibited magnetically enhanced accumulation in the cancer site, leading to significant inhibition of cancer growth with minimal side effects. This multifunctional MMSN will find great potential as a theranostic nanoplatform for cancer treatment. (c) 2015 Elsevier Ltd. All rights reserved.
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