Journal
IEEE TRANSACTIONS ON NANOBIOSCIENCE
Volume 18, Issue 4, Pages 661-668Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2019.2937327
Keywords
High intensity focused ultrasound; nanomedicine; gold nanoparticles; thermal ablation therapy; cancer treatment
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Government of Ontario through the Ontario Trillium Scholarships
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High intensity focused ultrasound (HIFU) has gained increasing attention as a noninvasive therapeutic method for wide range of biomedical applications from drug delivery to cancer treatment. However, high level of ultrasonic power required for efficient HIFU treatment can cause adverse effects such as damage to surrounding healthy tissues and skin burns. One of the strategies to improve the therapeutic mechanism of HIFU is to use ultrasound absorption agents during the treatment. The objectives of current study are to investigate the feasibility of adopting gold nanoparticles (AuNPs) as ultrasound absorption agents to enhance the HIFU thermal ablation when the NPs were injected locally to the focal region; and to examine the dose effects of AuNPs on both heating and cooling mechanisms of HIFU. To this end, we conducted an experimental study on tissue-mimicking phantoms where AuNPs were injected to the focal region under the guidance of ultrasound imaging. A set of thermal parameters including temperature, specific absorption rate of acoustic energy, and cooling rate were measured to monitor the mechanism of AuNPs-mediated HIFU. The results suggest that both heating and cooling rates of HIFU procedure could be greatly improved by injecting AuNPs, which demonstrates the feasibility of using AuNPs to reduce the level of ultrasonic power from extracorporeal source for HIFU treatment.
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