Journal
BIOMATERIALS
Volume 104, Issue -, Pages 129-137Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.07.013
Keywords
Repeated photothermal therapy; Responsive hydrogel; Cancer therapy; On-demand degradation; Non-invasive
Funding
- National Natural Science Foundation of China [21274044, 21207038]
- Science and Technology Commission of Shanghai Municipality [14JC1491100]
- Shanghai Pujiang Program [14PJD016]
- Shanghai Chenguang Program [12CG25]
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Near infrared-absorbing hydrogels are used for the repeated photothermal treatments of cancer. However, a long-term retention of hydrogel in the body leads to increased risk of toxicity. Here we developed an injectable and on-demand degradable hydrogel to conduct the repeated photothermal therapies (PTTs). Alginate-calcium hydrogel immobilized dendrimer-encapsulated platinum nanoparticles (DEPts) in its matrix represented excellent biocompatibility, and was degraded upon injecting chelates. Results from the in vivo studies reveal that the hydrogel/DEPts-mediated repeated PTTs suppressed tumor growth efficiently, and the hydrogel was degraded on-demand to allow renal secretion of DEPts out of the body. Furthermore, coating hydrogel/DEPts on the tumor instead of intratumoral injection could still ablate tumor efficiently. Our investigation provides a smart and safe hydrogel for photothermal cancer therapy. (C) 2016 Elsevier Ltd. All rights reserved.
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