Journal
BIOMATERIALS
Volume 100, Issue -, Pages 76-90Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.05.023
Keywords
NIR-responsive; Photosolvolysis; Hybrid nanoparticles; Au nanorods; Synergistic therapy
Funding
- National Science Foundation of China [501100001809:, 51573111, 51222304, 21202122]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R48]
- Ministry of Education of China [20130181110038]
- Natural Science Foundation of Zhejiang Province [LY15B020001]
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A near infrared (NIR) light responsive chromophore 7-(diethylamino)-4-(hydroxymethyl)-2H-chromen-2-one (DEACM) was synthesized and incorporated to beta-cyclodextrins with cRGD functionalized poly( ethylene glycol), the amphiphiles were coordinated with Au nanorods or nanoparticles to load anticancer drug doxorubicin (DOX) for fabricating hybrid nanoparticles. The pi-pi stacking interaction between DEACM and DOX was formed in the hybrid nanoparticles, which contributed to the high drug loading content. The Au nanorods or nanoparticles enhanced the photosolvolysis of DEACM under the irradiation of NIR with 808 nm wavelength and triggered the accelerated drug release from the nanoparticles. The drug loaded hybrid nanoparticles with NIR irradiation exhibited efficient inhibition effect on the proliferation of 4T1 breast cancer cells in vitro. The in vivo anticancer activity study on breast cancer bearing mice revealed that the hybrid nanoparticles containing Au nanorods exhibited excellent anticancer activity under the irradiation of 808 nm wavelength NIR with 800 mW. (C) 2016 Elsevier Ltd. All rights reserved.
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