Journal
BIOMATERIALS
Volume 100, Issue -, Pages 41-52Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.05.028
Keywords
BDNF; Brain repair; Microbubbles; Subcortical stroke; Ultrasound; White matter injury
Funding
- Spanish Neurovascular Network [PS12/01754, INVICTUS (RD12/0014/0006)]
- Research Institute Carlos III [CD12/00706]
- Spanish Ministry of Science and Innovation
- European Regional Development Fund
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Ultrasound-targeted microbubble destruction (UTMD) has been shown to be a promising tool to deliver proteins to select body areas. This study aimed to analyze whether UTMD was able to deliver brain derived neurotrophic factor (BDNF) to the brain, enhancing functional recovery and white matter repair, in an animal model of subcortical stroke induced by endothelin (ET)-1. UTMD was used to deliver BDNF to the brain 24 h after stroke. This technique was shown to be safe, given there were no cases of hemorrhagic transformation or blood brain barrier (BBB) leakage. UTMD treatment was associated with increased brain BDNF levels at 4 h after administration. Targeted ultrasound delivery of BDNF improved functional recovery associated with fiber tract connectivity restoration, increasing oligodendrocyte markers and remyelination compared to BDNF alone administration in an experimental animal model of white matter injury. (C) 2016 Elsevier Ltd. All rights reserved.
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