Journal
BIOMATERIALS
Volume 101, Issue -, Pages 217-228Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.05.043
Keywords
Supramolecular hydrogel; Host-guest complexation; Biomaterial carrier; Drug delivery; Tissue regeneration
Funding
- General Research Fund grant from Research Grants Council of Hong Kong [14202215]
- Shun Hing Institute of Advanced Engineering, The Chinese University of Hongkong, The Chinese University of Hong Kong [BME-p3-15]
- Health and Medical Research Fund, the Food and Health Bureau, the Government of the Hong Kong Special Administrative Region [02133356]
- National Natural Science Foundation of China [31570979]
- Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong
Ask authors/readers for more resources
Although considered promising materials for assisting organ regeneration, few hydrogels meet the stringent requirements of clinical translation on the preparation, application, mechanical property, bioadhesion, and biocompatibility of the hydrogels. Herein, we describe a facile supramolecular approach for preparing gelatin hydrogels with a wide array of desirable properties. Briefly, we first prepare a supramolecular gelatin macromer via the efficient host-guest complexation between the aromatic residues of gelatin and free diffusing photo-crosslinkable acrylated beta-cyclodextrin (beta-CD) monomers. The subsequent crosslinking of the macromers produces highly resilient supramolecular gelatin hydrogels that are solely crosslinked by the weak host-guest interactions between the gelatinous aromatic residues and beta-cyclodextrin (beta-CD). The obtained hydrogels are capable of sustaining excessive compressive and tensile strain, and they are capable of quick self healing after mechanical disruption. These hydrogels can be injected in the gelation state through surgical needles and re-molded to the targeted geometries while protecting the encapsulated cells. Moreover, the weak host-guest crosslinking likely facilitate the infiltration and migration of cells into the hydrogels. The excess beta-CDs in the hydrogels enable the hydrogel-tissue adhesion and enhance the loading and sustained delivery of hydrophobic drugs. The cell and animal studies show that such hydrogels support cell recruitment, differentiation, and bone regeneration, making them promising carrier biomaterials of therapeutic cells and drugs via minimally invasive procedures. (C) 2016 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available