Journal
BIOMATERIALS
Volume 106, Issue -, Pages 134-143Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.08.025
Keywords
Aminoglycoside; Hyperbranched polymer; Reduction-responsive; Antibacterial; Gene vectors
Funding
- NNSFC (National Natural Science Foundation of China) [51325304, 51473014, 51503012, 51521062]
- National Key Research and Development Program of China [2016YFC1100404]
- Beijing Natural Science Foundation [7151002]
- Innovation and Promotion Project of Beijing University of Chemical Technology
- Collaborative Innovation Center for Cardiovascular Disorders, Beijing Anzhen Hospital Affiliated to the Capital Medical University
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There is an increasing demand in developing of multifunctional materials with good antibacterial activity, biocompatibility and drug/gene delivery capability for next-generation biomedical applications. To achieve this purpose, in this work series of hydroxyl-rich hyperbranched polyaminoglycosides of gentamicin, tobramycin, and neomycin (HP and SS-HP with redox-responsive disulfide bonds) were readily synthesized via ring-opening reactions in a one-pot manner. Both HP and SS-HP exhibit high antibacterial activity toward Escherichia coli and Staphylococcus aureus. Meanwhile, the hemolysis assay of the above materials shows good biocompatibility. Moreover, SS-HPs show excellent gene transfection efficiency in vitro due to the breakdown of reduction-responsive disulfide bonds. For an in vivo anti-tumor assay, the SS-HP/p53 complexes exhibit potent inhibition capability to the growth of tumors. This study provides a promising approach for the design of next-generation multifunctional biomedical (C) 2016 Elsevier Ltd. All rights reserved.
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