Journal
BIOMATERIALS
Volume 88, Issue -, Pages 110-119Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2016.02.015
Keywords
Medical device; poly(ethylene-glycol)dimethacrylate; Minimally invasive surgery; Nano-cellulose fibers; Orthopedic implant; Photopolymerization
Funding
- SNF [10024003165465, 310030_153411]
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Nucleus pulposus replacements have been subjected to highly controversial discussions over the last 40 years. Their use has not yet resulted in a positive outcome to treat herniated disc or degenerated disc disease. The main reason is that not a single implant or tissue replacement was able to withstand the loads within an intervertebral disc. Here, we report on the development of a photo-polymerizable poly(ethylene glycol)dimethacrylate nano-fibrillated cellulose composite hydrogel which was tuned according to native tissue properties. Using a customized minimally-invasive medical device to inject and photopolymerize the hydrogel insitu, samples were implanted through an incision of 1 mm into an intervertebral disc of a bovine organ model to evaluate their long-term performance. When implanted into the bovine disc model, the composite hydrogel implant was able to significantly re-establish disc height after surgery (p < 0.0025). The height was maintained after 0.5 million loading cycles (p < 0.025). The mechanical resistance of the novel composite hydrogel material combined with the minimally invasive implantation procedure into a bovine disc resulted in a promising functional orthopedic implant for the replacement of the nucleus pulposus. (C) 2016 Elsevier Ltd. All rights reserved.
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