Journal
BIOMATERIALS
Volume 82, Issue -, Pages 194-207Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.12.015
Keywords
Peptide; Tumour-targeted nanocarrier; Gene and drug delivery; Liposome; Cancer therapy
Funding
- National Natural Science Foundation of China [81572973, 81302708]
- small and medium-sized enterprise innovation fund of Shanghai [1302H159400]
- Biological Medicine Industry-University-research Project of Shanghai [12DZ1941702]
- Program of the Twelfth Five-year Plan for Science and Technology Research of China [2012ZX09103-301-006]
- National Basic Research Program [2010CB529902]
- Biological Medicine Industry University-research Project of Shanghai [12DZ1941702]
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Development of rational vectors for efficient drug and gene delivery is crucial for cancer treatment. In this study, epidermal growth factor receptor (EGFR)-binding peptide amphiphile (PA) were used as the primary bilayer skeleton material to construct ultra-stable self-assembling peptide nanovesicle (SPV). The resulted EGFR-targeted SPV (ESPV) could efficiently encapsulate therapeutic cargos (drugs or small interfering RNAs [siRNAs]) or labelled fluorescent cargo (quantum dots [QDs]) and exhibited excellent affinity for EGFR-positive cancer cells. Moreover, ESPV could deliver more drug or plasmid DNA to tumour sites and promote gene expression (a three-fold ratio of ESPVs vs cationic liposomes). Notably, the individual delivery or co-delivery of doxorubicin (DOX) and the acetylcholinesterase (AChE) gene via the ESPVs resulted in excellent drug/gene delivery both in vitro and in vivo and exerted a significant growth-suppressing effect on a liver cancer xenograft. This nanoscale, targeted cargo-packaging technology may provide a new strategy for the design of highly targeted cancer therapy vectors. (C) 2015 Elsevier Ltd. All rights reserved.
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