Journal
BIOMATERIALS
Volume 77, Issue -, Pages 14-25Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.11.002
Keywords
Sunflower-type; Nanogel; Gene delivery; Bioimaging
Funding
- National Research Foundation of Korea (NRF) - Korean Government [NRF-2014R1A2A1A09002838]
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Sunflower-type nanogels carrying the QD 655 nanoprobe can be used for both gene transfection and bioimaging of hMSCs. The entry of sunflower-type nanogels into hMSCs can be possibly controlled by changing the formation of QDs. The physico-chemical properties of sunflower-type nanogels internalized by hMSCs were confirmed by AFM, SEM, TEM, gel retardation, and zeta-potential analyses. The bioimaging capacity was confirmed by confocal laser microscopy, Kodak imaging, and Xenogen imaging. Specifically, we investigated the cytotoxicity of sunflower-type nanogels via SNP analysis. Internalization of sunflower-type nanogels does not cause malfunction of hMSCs. (C) 2015 Elsevier Ltd. All rights reserved.
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