Journal
BIOMATERIALS
Volume 75, Issue -, Pages 203-222Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.10.035
Keywords
TiO2/Ag coatings; Micro-nano/porous; Poly(dopamine); Antibacterial coatings; Silver nanoparticles (AgNPs)
Funding
- Project of Scientific and Technical Plan of Beijing [Z141100002814008]
- National Natural Science Foundation of China [31370954]
- State Key Laboratory of Bioelectronics Open Research Fund of China (Chien-Shiung Wu Laboratory)
- National Basic Research Program (973) of China [2012CB619102]
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The therapeutic applications of silver nanoparticles (AgNPs) against biomedical device-associated infections (BAI), by local delivery, are encountered with risks of detachment, instability and nanotoxicity in physiological milieus. To firmly anchor AgNPs onto modified biomaterial surfaces through tight physicochemical interactions would potentially relieve these concerns. Herein, we present a strategy for hierarchical TiO2/Ag coating, in an attempt to endow medical titanium (Ti) with anticorrosion and antibacterial properties whilst maintaining normal biological functions. In brief, by harnessing the adhesion and reactivity of bioinspired polydopamine, silver nanoparticles were easily immobilized onto peripheral surface and incorporated into interior cavity of a micro/nanoporous TiO2 ceramic coating in situ grown from template Ti. The resulting coating protected the substrate well from corrosion and gave a sustained release of Ag+ up to 28 d. An interesting germicidal effect, termed trap-killing, was observed against Staphylococcus aureus strain. The multiple osteoblast responses, i.e. adherence, spreading, proliferation, and differentiation, were retained normal or promoted, via a putative surface-initiated self-regulation mechanism. After subcutaneous implantation for a month, the coated specimens elicited minimal, comparable inflammatory responses relative to the control. Moreover, this simple and safe functionalization strategy manifested a good degree of flexibility towards three-dimensional sophisticated objects. Expectedly, it can become a prospective bench to bedside solution to current challenges facing orthopedics. (C) 2015 Elsevier Ltd. All rights reserved.
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