Journal
BIOMATERIALS
Volume 81, Issue -, Pages 27-35Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.11.063
Keywords
Peripheral nerve repair; Neural scaffold; Fiber drawing; Tissue engineering
Funding
- Charles Stark Draper Laboratory University Research and Development Grant
- MIT MRSEC through the MRSEC Program of the National Science Foundation (NSF) [DMR-0819762, DMR-1419807]
- NSF CAREER Award [CBET-1253890]
- National Institute for Neurological Disorders and Stroke [R01 NS086804-01A1]
- Research Laboratory of Electronics
- Samsung Scholarship
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1253890] Funding Source: National Science Foundation
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Synthetic neural scaffolds hold promise to eventually replace nerve autografts for tissue repair following peripheral nerve injury. Despite substantial evidence for the influence of scaffold geometry and dimensions on the rate of axonal growth, systematic evaluation of these parameters remains a challenge due to limitations in materials processing. We have employed fiber drawing to engineer a wide spectrum of polymer-based neural scaffolds with varied geometries and core sizes. Using isolated whole dorsal root ganglia as an in vitro model system we have identified key features enhancing nerve growth within these fiber scaffolds. Our approach enabled straightforward integration of microscopic topography at the scale of nerve fascicles within the scaffold cores, which led to accelerated Schwann cell migration, as well as neurite growth and alignment. Our findings indicate that fiber drawing provides a scalable and versatile strategy for producing nerve guidance channels capable of controlling direction and accelerating the rate of axonal growth. (C) 2015 Published by Elsevier Ltd.
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