Journal
HEART & LUNG
Volume 49, Issue 2, Pages 151-157Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.hrtlng.2019.11.004
Keywords
Heart failure; Symptoms; Event-free survival
Funding
- Oregon Building Interdisciplinary Research Careers in Women's Health K12 Program - Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health (NIH) [K12HD043488]
- NIH/National Institute of Nursing Research [F31NR015936]
- American Heart Association [11BGIA7840062]
- Eunice Kennedy Shriver National Institute of Child Health & Human Development of the NIH [K12HD043488]
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Background: The relationship between physical and affective symptom clusters in heart failure (HF) is unclear. Objectives: To identify associations between physical and affective symptom clusters in HF and to quantify outcomes and determinants of symptom subgroups. Methods: This was a secondary analysis of data from two cohort studies among adults with HF. Physical and affective symptom clusters were compared using cross-classification modeling. Cox proportional hazards modeling and multinomial logistic regression were used to identify outcomes and determinants of symptom subgroups, respectively. Results: In this young, mostly male sample (n = 274), physical and affective symptom clusters were cross-classified in a model with acceptable fit. Three symptom subgroups were identified: congruent-mild (69.3%), incongruent (13.9%), and congruent-severe (16.8%). Compared to the congruent-mild symptom group, the incongruent symptom group had significantly worse 180-day event-free survival. Conclusion: Congruence between physical and affective symptom clusters should be considered when identifying patients at higher risk for poor outcomes. (C) 2019 Elsevier Inc. All rights reserved.
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