Journal
GENES & DEVELOPMENT
Volume 33, Issue 21-22, Pages 1460-1474Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.326470.119
Keywords
glycolysis; leukemia; metabolism; mitochondria; targeted therapy; Warburg effect
Categories
Funding
- Leukemia & Lymphoma Society [6531-18]
- National Institutes of Health [CA206501, CA210065]
- Innovative Research Award from the Alex Lemonade Stand Foundation
- Damon Runyon Cancer Research Foundation [DRSG 20-17]
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Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic pathways, and aberrant metabolism is central not only for leukemia proliferation and survival, but also mediates oncogene addiction with significant implications for the development of targeted therapies. This review explores leukemia metabolic circuitries feeding anabolism, redox potential, and energy required for tumor propagation with an emphasis on emerging therapeutic opportunities.
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