Journal
GASTROENTEROLOGY
Volume 158, Issue 2, Pages 303-321Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.gastro.2019.09.045
Keywords
CRC; MSI; Matrix; Microenvironment
Categories
Funding
- European Union [754923]
- Science Foundation Ireland [13/CDA/2183]
- Health Research Board [ILP-POR-2019-066]
- INSERM, Universite de Paris, Sorbonne University, CARPEM T8
- Labex Immuno-Oncology Excellence Program, Institut du Cancer, HTE Plan Cancer [C1608DS]
- Cartes d'Identite des Tumeurs Program from the Ligue Nationale Contre le Cancer
- Science Foundation Ireland (SFI) [13/CDA/2183] Funding Source: Science Foundation Ireland (SFI)
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Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of the tumor microenvironment serve as therapeutic targets and might be used as prognostic factors. For example, immune checkpoint inhibitors are used to treat tumors with microsatellite instability, and anti-angiogenic agents may be used in combination with other drugs to slow or inhibit tumor growth. We review the features of the colorectal tumor stroma that are associated with patient outcomes and discuss potential therapeutic agents that target these features.
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