Journal
BIOMARKERS IN MEDICINE
Volume 10, Issue 3, Pages 229-242Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm.16.3
Keywords
DNA damage; epigenetics; lipidomics; membrane phospholipids; poly(ADPribosyl)ation
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Funding
- Department of Biology, University of Naples 'Federico II'
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Establishing by statistical analyses whether the analyses of auto-modified poly(ADP-ribose) polymerase and erythrocyte membrane fatty acid composition (Fat Profile (R)), separately or in tandem, help monitoring the physio-pathology of the cell, and correlate with diseases, if present. Patients & methods: Ninety five subjects were interviewed and analyzed blindly. Blood lymphocytes and erythrocytes were prepared to assay poly(ADP-ribose) polymerase automodification and fatty acid based membrane lipidome, respectively. Results: Poly(ADP-ribose) polymerase automodification levels confirmed their correlation with DNA damage extent, and allowed monitoring disease activity, upon surgical/therapeutic treatment. Membrane lipidome profiles showed lipid unbalance mainly linked to inflammatory states. Statistically both tests were separately significant, and correlated each other within some pathologies. Conclusion: In the laboratory routine, both tests, separately or in tandem, might be a preliminary and helpful step to investigate the occurrence of a given disease. Their combination represents a promising integrated panel for sensible, noninvasive and routine health monitoring.
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