Journal
BIOMARKERS IN MEDICINE
Volume 10, Issue 7, Pages 743-755Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2015-0063
Keywords
annexin; biomarkers; cancer; flow cytometry; microparticles; microvesicles; thrombosis; tissue factor
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Microparticles (MPs) are small (0.1-1.0 mu m) membrane vesicles constitutively released from the surface of cells after activation and apoptosis. The clinical research on MPs is hampered by the limitations of the currently available detection methods. A correlation between MPs and venous thromboembolism (VTE) has been observed. The effects of MPs on thrombogenesis involve the exposure of phosphatidylserine, the vehiculation of tissue factor, and MP-induced intercellular cross-talk between inflammation and coagulation. This review will focus on the potential role of plasma MPs as biomarkers in detecting acute unprovoked VTE, predicting VTE occurrence in high-risk situations (mainly cancer), and ultimately, we will discuss currently available studies on the prognostic role of MPs to guide primary and secondary VTE prevention protocols.
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