Journal
BIOMARKERS
Volume 21, Issue 7, Pages 614-618Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2016.1171901
Keywords
Autism; ELISA; GFAP; Nogo-A
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Funding
- Batman University Scientific Research Project Coordination Center [BTUBAP-2014-YL1]
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Context: Improved biomarkers would facilitate the diagnosis and treatment of autism spectrum disorders (ASD). Objective: Our objective was to examine the levels of Nogo-A and glial fibrillary acidic protein (GFAP) in children with ASD. Materials and methods: Serum concentrations of GFAP and Nogo-A were determined by enzyme-linked immunosorbent assay. Results: In this preliminary study, we found that serum Nogo-A was not found significantly different between groups, while serum levels of GFAP were significantly lower in ASD than controls. Discussion and conclusions: It will be of great interest to determine other potential causes of elevated serum levels of GFAP, and whether this elevation has any phenotypic effect.
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