Journal
BIOMARKERS
Volume 22, Issue 2, Pages 127-132Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1354750X.2016.1252949
Keywords
Liver cirrhosis; IGF-I; ascites; portal hypertension
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [479801/2011-8]
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Context: IGF-I serum levels are suppressed in cirrhosis, but its prognostic significance is unknown. Objectives: To investigate the prognostic value of IGF-I in patients admitted for acute decompensation of cirrhosis. Materials and methods: Cohort study that included 103 patients. IGF-I was measured by enzymelinked immunosorbent assay (ELISA). Results: Ninety-day mortality was 26.2% and it was independently associated with MELD, age and IGFI. The Kaplan-Meier survival probability at 90 days was 94.3% in patients with IGF-I >= 13 mu g/mL and 63.2% for patients with IGF-I < 13 ng/mL (p = .001). Discussion and conclusion: IGF-I levels are independently associated with mortality in acute decompensation of cirrhosis.
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