Journal
FOOD AND CHEMICAL TOXICOLOGY
Volume 135, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2019.110886
Keywords
Holothuria leucospilota; Polysaccharide; Type 2 diabetes mellitus; Gut microbiota; Goto-kakizaki rats
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Funding
- National Key R&D Program of China [2018YFC0311205]
- Project of Haikou Ocean and Fisheries Bureau [HHCL201804]
- Scientific Research Foundation of Hainan University [KYQD1609]
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Diabetes mellitus has become a worldwide concern in recent years. In this study, the effect of Holothuria leucospilota polysaccharide (HLP) on type 2 diabetes mellitus (T2DM) was investigated in Goto-Kakizaki (GK) rats. The results showed that HLP significantly improved glucose intolerance and regulated blood lipid and hormone levels (p < 0.05). Pathological analysis showed that HLP repaired the impairments of the pancreas and colon in diabetic rats. In addition, a high dose of HLP (200 mg/kg) significantly upregulated the gene expression of peroxisome proliferator-activated receptor-alpha (PPAR-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), phosphoinositide 3-kinase (PI3K), protein kinase B (PKB/AKT), glucose transporter-4 (GLUT4) and anti-apoptotic (Bcl-2), and downregulated the mRNA levels of pro-apoptotic (Bax) and cluster of differentiation 36 (CD36) in diabetic rats (p < 0.05). Furthermore, HLP treatment increased the short-chain fatty acid-producing bacteria and decreased the opportunistic bacterial pathogen in the feces of diabetic rats. These results demonstrated that HLP has the potential to ameliorate T2DM in GK rats.
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