Journal
FITOTERAPIA
Volume 139, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2019.104391
Keywords
Sophora tonkinensis Gagnep.; Alkaloid; Anti-inflammatory activity
Categories
Funding
- National Natural Science Foundation of China [81803376, 81473116, 81673319, 81673670, 81402801, 81973544]
- Science and Technology Planning Project of Guangdong Province [2016A030303011, 20168030301004]
- Science and Technology Planning Project of Guangzhou City [201707010399]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme [GDHVPS2018]
- scientific research project of the Southern Medical University [CX2018N002]
- Natural Science Foundation of Guangdong Province [2017A030313732]
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Two new quinolizidine-based alkaloids (2 and 12), along with ten known ones (1, 3-11) were isolated from the roots of S. tonkinensis. Their structures were determined by spectroscopic data (including NMR, MS, IR, and UV), X-ray single crystal diffraction, electronic circular dichroism analyses (ECD), and comparing with related literatures. Compounds 1, 3-12 at non-toxic concentrations exhibited potent anti-inflammatory activities according to in vitro and in vivo anti-inflammatory tests. Among them, (-)-anagyrine (4), sophocarpine (8), 14 beta-hydroxymatrine (10), and 7 beta-sophoramine (12) showed more potent in vitro anti-inflammatory activities, and 5 alpha,14 beta-dihydroxymatrine (2), (-)-anagyrine (4), sophocarpine (8), and 5 alpha-hydroxymatrine (9) exhibited better in vivo anti-inflammatory effects.
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