Review: Antibacterial components of the Bivalve's immune system and the potential of freshwater bivalves as a source of new antibacterial compounds

Antibacterial research is reaching new heights due to the increasing demand for the discovery of new substances capable of inhibiting bacteria, especially to respond to the appearance of more and more multi-resistant strains. Bivalves show enormous potential for the finding of new antibacterial compounds, although for that to be further explored, more research needs to be made regarding the immune system of these organisms. Beyond their primary cellular component responsible for bacterial recognition and destruction, the haemocytes, bivalves have various other antibacterial units dissolved in the haemolymph that intervene in the defense against bacterial infections, from the recognition factors that detect different bacteria to the effector molecules carrying destructive properties. Moreover, to better comprehend the immune system, it is important to understand the different survival strategies that bacteria possess in order to stay alive from the host's defenses. This work reviews the current literature regarding the components that intervene in a bacterial infection, as well as discussing the enormous potential that freshwater bivalves have in the discovery of new antibacterial compounds.