Journal
FERTILITY AND STERILITY
Volume 113, Issue 1, Pages 217-223Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2019.08.089
Keywords
Telomeres; cumulus cells; IVF; ovarian biology
Categories
Funding
- IVIRMA Global
Ask authors/readers for more resources
Objective: To investigate whether telomere length (TL) in granulosa cells (GC) or cumulus cells (CC) correlates with TL in leukocytes (L). Design: Prospective noninterventional study. Setting: Private assisted reproductive technology center. Patient(s): Thirty-five egg donors were included in the study. Interventions(s): None. Main Outcome Measure(s): Average relative leukocyte telomere length (LTL), cumulus cell telomere length (CCTL), and granulosa cell telomere length (GCTL) measurements from each study subject. Result(s): Participants had a mean age of 25.43 +/- 4.57 years, antimullerian hormone level of 1.90 +/- 0.92 ng/mL, antral follicle count of 23.29 +/- 5.11, and the mean number of mature oocytes retrieved was 23.29 +/- 9.13. No significant association between these variables and GCTL, CCTL, or LTL was found. In addition, no correlation was observed between TL measurements of L vs. CC, L vs. GC, or CC vs. GC. Interestingly, CCTL was significantly higher than LTL (1.54-fold), although no significant differences were found between GCTL vs. CCTL or GCTL vs. LTL. Conclusion(s): CC from mature follicles have significantly longer telomeres than L, suggesting that the follicular environment could possess different mechanisms to cope against telomere shortening compared with other somatic tissues. Furthermore, these data do not support the utility of telomere DNA measurement in L as an estimate of TL in follicular cells. American Society for Reproductive Medicine.)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available