Journal
BIOMACROMOLECULES
Volume 17, Issue 3, Pages 818-829Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.5b01543
Keywords
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Funding
- National Natural Science Foundation of China [51403197, 51473164, 51273195, 51203152]
- Ministry of Science and Technology of China (International Cooperation and Communication Program) [2014DFG52510]
- Joint funded program of Chinese Academy of Sciences
- Japan Society for Promotion of Science [GJHZ1519]
- Program of Scientific Development of Jilin Province [20130201005GX]
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Nanocomposite of hydroxyapatite (HA) surface grafted with L-lactic acid oligomer (LAc oligomer) (op-HA) showed improved interface compatibility, mechanical property, and biocompatibility in our previous study. In this paper, composite scaffolds of op-HA with controlled grafting different amounts of LAc oligomer (1.1, 5.2, and 9.1 wt %) were fabricated and implanted to repair rabbit radius defects. The dispersion of op-HA nanoparticles was more uniform than n-HA in chloroform and nanocomposites scaffold. Calcium and phosphorus exposure, in vitro biomineralization ability, and cell proliferation were much higher in the op-HA(1.1) (wt) (%)/PLGA scaffolds than the other groups. The osteodifferentiation and bone fusion in animal tests were significantly enhanced for op-HA(5.2) (wt) (%)/PLGA scaffolds. The results indicated that the grafted LAc oligomer of 5.2 or 9.1 wt %, which formed a barrier layer on the HA surface, prevented the exposure of nucleation sites. The shielded nucleation sites of op-HA particles (5.2 wt %) might be easily exposed as the grafted LAc oligomer was decomposed easily by enzyme systems in vivo. Findings from this study have revealed that grafting 1.1 wt % amount of LAc oligomer on hydroxyapatite could improve in vitro mineralization, and 5.2 wt % could promote in vivo osteogenesis capacity of composite scaffolds.
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