Journal
BIOMACROMOLECULES
Volume 17, Issue 6, Pages 1930-1938Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.5b01577
Keywords
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Funding
- Rachadapisak Sompote Fund for Postdoctoral Fellowship, Chulalongkorn University
- University of South Carolina
- National Natural Science Foundation of China [21429401, 21374119]
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This study focuses on the development of injectable hydrogels to mimic the cartilage microenvironment using hyaluronic acid (HA) derivatives as starting materials. Cysteine-inserted Tobacco mosaic virus (TMV) mutants (TMV1cys) could be cross-linked to methacrylated hyaluronic acid (MeHA) polymers by thiol-ene click chemistry and form hydrogels under physiological condition. The resulting hydrogels could promote in vitro chondrogenesis of bone marrow mesenchymal stem cells (BMSCs) significantly higher than that in the TMV-free HA hydrogels by upregulating bone morphogenetic protein-2 (BMP-2) expression and enhancing collagen accumulation.
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