Related references
Note: Only part of the references are listed.DRP1-dependent apoptotic mitochondrial fission occurs independently of SAX, BAK and APAF1 to amplify cell death by BID and oxidative stress
Bjorn Oettinghaus et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2016)
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2+ signaling
Mart Bittremieux et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)
Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy
Rita M. L. La Rovere et al.
CELL CALCIUM (2016)
Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death
Giampaolo Morciano et al.
MOLECULAR BIOLOGY OF THE CELL (2016)
Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines
Esther P. Jane et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications
Carlotta Giorgi et al.
ANTIOXIDANTS & REDOX SIGNALING (2015)
Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells
Weilin Wang et al.
CANCER LETTERS (2015)
The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage
Tatiana Varanita et al.
CELL METABOLISM (2015)
Mitofusin 2 ablation increases endoplasmic reticulum-mitochondria coupling
Riccardo Filadi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Cell Death Signaling
Douglas R. Green et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner
Shankar Varadarajan et al.
ONCOTARGET (2015)
Mitochondrial Ca2+ remodeling is a prime factor in oncogenic behavior
Alessandro Rimessi et al.
FRONTIERS IN ONCOLOGY (2015)
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
L. Galluzzi et al.
CELL DEATH AND DIFFERENTIATION (2015)
CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo
G. P. Gregory et al.
LEUKEMIA (2015)
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition
M. Bonora et al.
ONCOGENE (2015)
The endoplasmic reticulum-mitochondria connection: One touch, multiple functions
Saverio Marchi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2014)
Distribution and Apoptotic Function of Outer Membrane Proteins Depend on Mitochondrial Fusion
David Weaver et al.
MOLECULAR CELL (2014)
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Peter E. Czabotar et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Persistent Mitochondrial Hyperfusion Promotes G2/M Accumulation and Caspase-Dependent Cell Death
Laura M. Westrate et al.
PLOS ONE (2014)
Many players in BCL-2 family affairs
Tudor Moldoveanu et al.
TRENDS IN BIOCHEMICAL SCIENCES (2014)
MCL1 is critical for mitochondrial function and autophagy in the heart
Robert L. Thomas et al.
AUTOPHAGY (2013)
Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance
Marc Schneeberger et al.
CELL (2013)
Evaluation and critical assessment of putative MCL-1 inhibitors
S. Varadarajan et al.
CELL DEATH AND DIFFERENTIATION (2013)
A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition
Daniel J. Goff et al.
CELL STEM CELL (2013)
Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein
Chris Froehlich et al.
EMBO JOURNAL (2013)
Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure
Robert L. Thomas et al.
GENES & DEVELOPMENT (2013)
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
Oliver C. Loson et al.
MOLECULAR BIOLOGY OF THE CELL (2013)
A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis
Hongmei Li et al.
NATURE CELL BIOLOGY (2013)
MCL-1ES Induces MCL-1L-Dependent BAX- and BAK-Independent Mitochondrial Apoptosis
Jae-Hong Kim et al.
PLOS ONE (2013)
Mitochondrial Regulation of Cell Death
Stephen W. G. Tait et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Mechanisms of Action of Bcl-2 Family Proteins
Aisha Shamas-Din et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis
Shankar Varadarajan et al.
NEOPLASIA (2013)
Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner
Seung-Wook Ryu et al.
CANCER LETTERS (2012)
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum
S. Varadarajan et al.
CELL DEATH AND DIFFERENTIATION (2012)
Discovery of Marinopyrrole A (Maritoclax) as a Selective Mcl-1 Antagonist that Overcomes ABT-737 Resistance by Binding to and Targeting Mcl-1 for Proteasomal Degradation
Kenichiro Doi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Endoplasmic reticulum-specific BH3-only protein BNIP1 induces mitochondrial fragmentation in a Bcl-2- and Drp1-dependent manner
Seung-Wook Ryu et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2012)
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
Rhonda M. Perciavalle et al.
NATURE CELL BIOLOGY (2012)
Mitofusin-2 Independent Juxtaposition of Endoplasmic Reticulum and Mitochondria: An Ultrastructural Study
Pierre Cosson et al.
PLOS ONE (2012)
ATP synthesis and storage
Massimo Bonora et al.
PURINERGIC SIGNALLING (2012)
Calcium signaling around Mitochondria Associated Membranes (MAMs)
Simone Patergnani et al.
CELL COMMUNICATION AND SIGNALING (2011)
Apoptosis and oncogenesis: give and take in the BCL-2 family
Fabien Llambi et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2011)
MiD49 and MiD51, new components of the mitochondrial fission machinery
Catherine S. Palmer et al.
EMBO REPORTS (2011)
Identification of a Novel Mcl-1 Protein Binding Motif
William J. Placzek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
ER Tubules Mark Sites of Mitochondrial Division
Jonathan R. Friedman et al.
SCIENCE (2011)
An optically pure apogossypolone derivative as potent pan -active inhibitor of anti-apoptotic BcI-2 family proteins
Jun Wei et al.
FRONTIERS IN ONCOLOGY (2011)
Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1α/Mitofusin-2 Regulatory Pathway in Response to Physical Activity
Maria Isabel Hernandez-Alvarez et al.
DIABETES CARE (2010)
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli
Veronica Costa et al.
EMBO MOLECULAR MEDICINE (2010)
The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms
Thomas Landes et al.
EMBO REPORTS (2010)
Mcl-1; the molecular regulation of protein function
Luke W. Thomas et al.
FEBS LETTERS (2010)
The BCL-2 Family Reunion
Jerry E. Chipuk et al.
MOLECULAR CELL (2010)
The dynamic plant chondriome
David C. Logan
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2010)
Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
Desiree A. Steimer et al.
BLOOD (2009)
Mcl-1 is a potential therapeutic target in multiple types of cancer
C. Akgul
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
SLP-2 is required for stress-induced mitochondrial hyperfusion
Daniel Tondera et al.
EMBO JOURNAL (2009)
MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death
Jae-Hong Kim et al.
FEBS LETTERS (2009)
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
Naotada Ishihara et al.
NATURE CELL BIOLOGY (2009)
Mitochondrial Dynamics in Mammalian Health and Disease
Marc Liesa et al.
PHYSIOLOGICAL REVIEWS (2009)
The versatility of mitochondrial calcium signals: From stimulation of cell metabolism to induction of cell death
Alessandro Rimessi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2008)
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
M. Kvansakul et al.
CELL DEATH AND DIFFERENTIATION (2008)
Unique Biology of Mcl-1: Therapeutic Opportunities in Cancer
Gordon Shore et al.
CURRENT MOLECULAR MEDICINE (2008)
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization
Ann Cassidy-Stone et al.
DEVELOPMENTAL CELL (2008)
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig et al.
EMBO JOURNAL (2008)
Mitochondrial dynamics and apoptosis
Der-Fen Suen et al.
GENES & DEVELOPMENT (2008)
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage
Nicole Arbour et al.
JOURNAL OF NEUROSCIENCE (2008)
An essential role for MCL-1 in ATR-mediated CHK1 phosphorylation
Sarwat Jamil et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization
Ryuji Yamaguchi et al.
MOLECULAR CELL (2008)
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Olga Martins de Brito et al.
NATURE (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
G. M. Cereghetti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
Jerry E. Chipuk et al.
TRENDS IN CELL BIOLOGY (2008)
Functions and dysfunctions of mitochondrial dynamics
Scott A. Detmer et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death
J. Thomas Cribbs et al.
EMBO REPORTS (2007)
Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage
Lorena Griparic et al.
JOURNAL OF CELL BIOLOGY (2007)
Mitochondrial fusion protects against neurodegeneration in the cerebellum
Hsiuchen Chen et al.
CELL (2007)
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
Seungmin Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins
Craig Brooks et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis
J. Estaquier et al.
CELL DEATH AND DIFFERENTIATION (2007)
Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3β activity and associates with poor prognosis in human breast cancer
Qingqing Ding et al.
CANCER RESEARCH (2007)
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
Sylwia Wasiak et al.
JOURNAL OF CELL BIOLOGY (2007)
Orchestration of lymphocyte chemotaxis by mitochondrial dynamics
Silvia Campello et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Role of Bax and Bak in mitochondrial morphogenesis
Mariusz Karbowski et al.
NATURE (2006)
Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis
Philippe A. Parone et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
Christian Frezza et al.
CELL (2006)
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1
Naotada Ishihara et al.
EMBO JOURNAL (2006)
Mitochondrial dynamics and Ca2+ signaling
G. Szabadkai et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2006)
Shared components of mitochondrial and peroxisomal division
Michael Schrader
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2006)
Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA
Akitsugu Sato et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2006)
Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics
P Delivani et al.
MOLECULAR CELL (2006)
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
TZ Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture
D. T. W. Chang et al.
NEUROSCIENCE (2006)
Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1
TZ Yu et al.
JOURNAL OF CELL SCIENCE (2005)
Disruption of fusion results in mitochondrial heterogeneity and dysfunction
HC Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis
Q Zhong et al.
CELL (2005)
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival
S Wuillème-Toumi et al.
LEUKEMIA (2005)
Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization
M Neuspiel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Disruption of Mcl-1•Bim complex in granzyme B-mediated mitochondrial apoptosis
J Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis
M Germain et al.
EMBO JOURNAL (2005)
Mitochondria, oxidants, and aging
RS Balaban et al.
CELL (2005)
Mitochondrial fusion intermediates revealed in vitro
S Meeusen et al.
SCIENCE (2004)
MCL-1 expression in B-cell non-Hodgkin's lymphomas
JH Cho-Vega et al.
HUMAN PATHOLOGY (2004)
Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis
D Tondera et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol
AM Domina et al.
ONCOGENE (2004)
Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia
A Saxena et al.
AMERICAN JOURNAL OF HEMATOLOGY (2004)
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
YJ Lee et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis
M Herrant et al.
ONCOGENE (2004)
Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis
G Szabadkai et al.
MOLECULAR CELL (2004)
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A
S Züchner et al.
NATURE GENETICS (2004)
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis
A Olichon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
HC Chen et al.
JOURNAL OF CELL BIOLOGY (2003)
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
M Karbowski et al.
JOURNAL OF CELL BIOLOGY (2002)
Phosphorylation and inactivation of myelbid cell leukemia 1 by JNK in response to oxidative stress
S Inoshita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Antisense strategy shows that Mcl-1 rather than Bcl-2 or BCI-xL is an essential survival protein of human myeloma cells
S Derenne et al.
BLOOD (2002)
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis
L Scorrano et al.
DEVELOPMENTAL CELL (2002)
Mutation spectrum and splicing variants in the OPA1 gene
C Delettre et al.
HUMAN GENETICS (2001)
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis
S Frank et al.
DEVELOPMENTAL CELL (2001)
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells
E Smirnova et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer
HHJ Backus et al.
ANNALS OF ONCOLOGY (2001)
Regulation of apoptosis and cell cycle progression by MCL1 - Differential role of proliferating cell nuclear antigen
K Fujise et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain
J Bae et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
In vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins
C Akgul et al.
FEBS LETTERS (2000)
Exon skipping in Mcl-1 results in a Bcl-2 homology domain 3 only gene product that promotes cell death
CD Bingle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)