Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 186, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2019.111893
Keywords
Pyrazolone; Antimicrobial; Antitumor; CNS agents; Anti-inflammatory; Derivatives
Categories
Funding
- Changjiang Scholars and Innovative Research Team in Universities, Ministry of Education of China [IRT_15R55]
- 9th Group of Hundred-Talent Program of Shaanxi Province
- International Science AMP
- Technology Cooperation Program of Shaanxi Province [2019KWZ-001]
- Natural Science Foundation of Shaanxi Province, China [2017JM8054]
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The pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on. Meanwhile, SAR (Structure-Activity Relationship) investigations have drawn attentions among medicinal chemists, along with a plenty of analogues have been derived for multiple targets. In this review, we comprehensively summarize the biological activity and SAR for pyrazolone analogues, wishing to give an overall retrospect and prospect on the pyrazolone derivatives. (C) 2019 Elsevier Masson SAS. All rights reserved.
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