Journal
ENVIRONMENTAL POLLUTION
Volume 254, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2019.112978
Keywords
Amino modification; Reproductive toxicity; Gonad development; Reproductive capacity; Nanopolystyrene; Caenorhabditis elegans
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Funding
- Scientific Research Foundation of the Graduate School of Southeast University [YBPY1945]
- Guangdong Provincial Key Laboratory of Environmental Pollution and Health [GDKLEEH201812]
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Although amino modified nanopolystyrene could cause toxicity on environmental organisms, the effect of amino modification on nanopolystyrene toxicity is still largely unclear. We here employed Caenorhabditis elegans as an animal model to compare the effects between pristine and amino modified nanopolystyrene particles in inducing reproductive toxicity. Nanopolystyrene (35 nm) could cause the damage on gonad development as indicated by the endpoints of number of total germline cells, length of gonad arm, and relative area of gonad arm. Nanopolystyrene exposure also reduced the reproductive capacity as reflected by the endpoints of brood size and number of fertilized eggs in uterus. Moreover, amino modification enhanced nanopolystyrene toxicity on both the gonad development and the reproductive capacity. Additionally, induction of germline apoptosis and formation of germline DNA damage contributed to the enhancement of nanopolystyrene toxicity in reducing reproductive capacity by amino modification. Our results highlight the potential environmental risk of amino modified nanopolystyrene in inducing reproductive toxicity on gonad development and reproductive capacity of environmental organisms. (C) 2019 Elsevier Ltd. All rights reserved.
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