Journal
DIABETES
Volume 69, Issue 2, Pages 259-266Publisher
AMER DIABETES ASSOC
DOI: 10.2337/db19-0606
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Funding
- NIDDK [R01DK107859, R01DK105072, R01DK102696, R01DK099512]
- Wellcome Trust Institutional Strategic Support Award [WT097835MF]
- University of Manchester Research Infrastructure Fund
- Spanish Government of Investigation, Development and Innovation [SAF2017-84135-R]
- European Regional Development Fund (FEDER)
- Seneca Foundation [20795/PI/18]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant [R01DK105072]
- National Heart, Lung, and Blood Institute [R01HL118601, R01HL140574]
- MGH Research Scholar Fund
- University of Manchester (Regional Innovation Funding)
- MRC [MR/P012167/1] Funding Source: UKRI
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Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes; however, whether they exert joint effects to exacerbate type 2 diabetes risk is unknown. Among employed participants of European ancestry in the UK Biobank (N = 189,488), we aimed to test the cross-sectional independent associations and joint interaction effects of these risk factors on odds of type 2 diabetes (n = 5,042 cases) and HbA(1c) levels (n = 175,156). Current shift work, definite morning or evening preference, and MTNR1B rs10830963 risk allele associated with type 2 diabetes and HbA(1c) levels. The effect of rs10830963 was not modified by shift work schedules. While marginal evidence of interaction between self-reported morningness-eveningness preference and rs10830963 on risk of type 2 diabetes was seen, this interaction did not persist when analysis was expanded to include all participants regardless of employment status and when accelerometer-derived sleep midpoint was used as an objective measure of morningness-eveningness preference. Our findings suggest that MTNR1B risk allele carriers who carry out shift work or have more extreme morningness-eveningness preference may not have enhanced risk of type 2 diabetes.
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