Journal
DEVELOPMENT
Volume 146, Issue 22, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.182154
Keywords
Gene regulatory network; Hedgehog; Neural tube; Neurogenesis; Neuronal diversity; Patterning
Categories
Funding
- Francis Crick Institute from Cancer Research UK [FC001051]
- UK Medical Research Council [FC001051]
- Wellcome Trust [FC001051]
- European Research Council under the European Union's Horizon 2020 research and innovation programme [742138]
- Human Frontier Science Program postdoctoral fellowship [LTF000401/2014-L]
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The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types arranged in characteristic positions. During development, these different types of neurons differentiate from transcriptionally distinct neural progenitors that are arrayed in discrete domains along the dorsal-ventral and anterior-posterior axes of the embryonic spinal cord. This organization arises in response to morphogen gradients acting upstream of a gene regulatory network, the architecture of which determines the spatial and temporal pattern of gene expression. In recent years, substantial progress has been made in deciphering the regulatory network that underlies the specification of distinct progenitor and neuronal cell identities. In this Review, we outline how distinct neuronal cell identities are established in response to spatial and temporal patterning systems, and outline novel experimental approaches to study the emergence and function of neuronal diversity in the spinal cord.
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