Journal
CURRENT ORGANIC SYNTHESIS
Volume 16, Issue 8, Pages 1078-1104Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570179416666191007092548
Keywords
Green chemistry; synthesis; biological activity; imidazole; anti-cancer; antibacterial
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Funding
- UGC -MANF [2018-19-RAJ-91971]
- CSIR [09/172(0099)/2019-EMR-I]
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Heterocyclic compounds are pervasive in many areas of life and one of the heterocycles, imidazole is a unique heterocyclic five-membered aromatic compound having two sp(2) hybridized nitrogen atoms. Its integral name is 1, 3 diazole and previously, it was known as glyoxalin. This moiety has achieved a considerable place among scientists in recent years by reason of its divergent synthetic strategies and uncommon biological and pharmacological activities, for example, anti-convulsant, anti-microbial, anti-cancer, anti-inflammatory, anti-tumor, anti-viral, anti-ulcer, analgesic, etc. Due to distinct therapeutic actions, it is still an engrossed area of research. Researchers currently are inventing new greener methods to synthesize its derivatives and to improve its pharmacological activities. The purpose of this review is to study the literature that can help researchers to explore this area, its prevailing program for synthesis in environmentally friendly conditions and biological profile throughout past decades.
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